Global 3D Cell Culture Market Outlook 2030

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  • Published Date:
    14 Sep 2021
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    Healthcare & Pharmaceuticals
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Impact Analysis on the Growth of Market

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Market Overview:

By the end of 2021, the global 3D cell culture market is estimated to be worth USD ~1.8 billion and is expected to grow at a compound annual growth rate (CAGR) of 12% during the forecast period 2022-2030. Since 3D culture can closely simulate typical organ morphology and microstructure, they are widely used in studies that require in vivo model systems to analyze the effects of foreign drugs on body tissues and organs. In addition, the biomimetic tissue structure used to generate 3D organotypic structures has led a large number of research entities to adopt 3D cell culture technology. In addition, the use of 3D tissue engineering models for Covid-19, cancer and other clinical diseases has become an alternative to traditional techniques. Compared with two-dimensional technology, this also shows great potential to provide a relatively simple and inexpensive in vitro tumor host environment.

The huge utility of 3D models in Covid-19 and respiratory disease research is expected to provide important growth opportunities for the market. Organoids from the airway and air-liquid interface have been used as tools for the discovery and development of antiviral drugs, as well as an experimental virology platform for studying the immune response and infectiousness of SARS-CoV-2. Stent-based and stent-free technologies facilitate the biomanufacturing of realistic models that can be used to develop new therapies and vaccines against Covid-19.

Other important factors driving market growth include the launch of new products and the widespread application of 3D protocols in biological research. For example, in December 2020, Canadian biotechnology company eNUVIO Inc. launched EB-Plate, a fully reusable 3D cell culture microplate. It is expected that this will reduce the waste of disposable plastics, increase the practicality of 3D microplates, and promote the movement of zero waste in the laboratory.

Likewise, standard 2D analysis methods can be easily applied to RAFT 3D cultures manufactured by Lonza. Because these new technologies do not require many changes to existing 2D culture methods, they are adopted by many laboratories around the world. In addition, Lonza has also developed a 3D cell culture model to strengthen research in the field of liver signaling pathways and drug-induced liver injury to strengthen in vitro liver toxicity testing.


In 2020, stent-based technology will account for the largest revenue share, exceeding 68.96%. The use of hydrogel as a scaffold in research based on 3-D cell culture can combine complex mechanical and biochemical markers as a mirror for local people. Extracellular matrix.

In addition, the launch of new products and the increasing demand for advancements in hydrogels provide a powerful platform for human and cellular physiology research, which is expected to drive market growth in the next few years. In January 2021, researchers from the US University of Science and Technology South China developed a 3D printing method for highly stretchable hydrogels.

This helps overcome the limitations associated with the performance and functionality of hydrogel polymer-based stents. In January 2021, Adocia, a Paris-based biopharmaceutical company, developed a hydrogel scaffold that can be used for type 1 diabetes cell therapy.

The increasing popularity and popularity of nanotechnology in biomedical research is expected to create potential growth. The prospect of nanofiber scaffolds, thereby increasing the sales and demand for scaffold technology. Magnetic levitation assembly of 3D tissue structure is a new, fast-growing, label-free, scaffold-free tissue engineering method. This is expected to drive the non-scaffolding market segment with the fastest compound annual growth rate during the forecast period.


The cancer field will dominate the market with the largest revenue share of 22% in 2020. The use of spheres as a model system in the development of cancer treatments has promoted research and development in this area. In addition, the use of 3-D cell models in preclinical testing and screening to study cancer biology is expected to increase revenue in this field.

A study in January 2021 reported the development of tumor models based on 3D printed polysaccharide hydrogels, which can be used for high-throughput screening of anticancer drugs. Within the framework of this research, the researchers aim to develop hydrogels that can effectively simulate the tumor microenvironment and show sufficient biocompatibility, rheological properties, and printability.

These developments have led to increased use of stent-based cancer technology, and the field of stem cell research is expected to record the fastest compound annual growth rate between 2021 and 2028. It is expected that the increased application of 3D cell culture platforms in regenerative medicine will promote the growth of market segments. In January 2020, Histogen, Inc., dedicated to the development of regenerative medicine, merged with Conatus Pharmaceuticals, Inc.. The latter demonstrated a powerful combination of unique clinical drug candidates, including extracellular matrix scaffolds for targeted therapy. Diseases related to articular cartilage.


The pharmaceutical and biotechnology industry sectors generated over 44% of the highest revenue share in 2020. 3D cell culture has advantages in terms of optimal oxygen and nutrient gradients, non-exposure uniformity of cells in the sphere to drugs, and compared with 2D cell culture, real cell interactions to study candidate drugs.

These factors make 3D cell culture more suitable for drug discovery and development, thereby driving demand. The urgent need for faster and more accurate diagnostic services and the superiority of 3D models to 2D models to provide detailed physiological information are driving the growth of diagnostic centers and hospital departments. In addition, the existence of diagnostic centers that actively participate in providing 3D models for advanced research (such as Kiyatec) is expected to drive the growth of this segment in the next few years.

Academic institutions and industrial laboratories are also expected to contribute to the growing share of this market. It is expected that the 3D cell culture system training programs and seminars provided by the institute will drive the demand for 3D cell culture products and systems during the forecast period.


North America will lead the global market in 2020, occupying the largest revenue share, exceeding 40%. As private and government funds can be used to develop advanced 3D cell culture models, high expenditures in healthcare, and the presence of a large number of universities and research organizations, the region will maintain its leading position throughout the forecast period.

Based on method. In December 2020, researchers from the Mayo Clinic and Terasaki Research Institute in the United States developed a visible hydrogel that can be used to monitor and control bleeding. The "2020: New Vision " initiative of the U.S. The Department of Health and Human Services recognizes that regenerative medicine is at the forefront of healthcare.

The transformative impact of using regenerative medicine in the clinical phase is critical to translational progress and technological innovation. However, due to increased investment by international companies in emerging economies in the region, the Asia-Pacific region is expected to become the fastest-growing regional market from 2021 to 2028.


Major market participants focus on the release of new products and cooperation with other participants to increase market share. For example, in June 2020, Corning launched the Corning X-SERIES cell processing platform for gene and cell therapy applications. The platform provides sterile, fast, efficient and automated processing.

This product is manufactured by ThermoGenesis Holdings, Inc. In the same month, the company also released Corning Matrigel 3D Matrix Plates, which provides more convenient and consistent cell culture options that can be used to support organoid and sphere culture models at any time. Some of the major players in the global 3D cell culture market include: Merck KGaAThermo Fisher Scientific, Inc. Promocell GmbH Greiner Bio One International GmbH Corning, Inc. 3D Biomatrix Lonza Avantor Performance Materials, LLC Tecan Trading AG 3D Biotek LLC Global Cell Solutions, Inc. Sphere


The report forecasts global, regional and national revenue growth, and analyzes the latest industry trends in each sub-segment from 2022-2030. For the purpose of this research, Kenneth Research, Inc. has segmented the global 3D cell culture market report based on technology, application, end use, and region: Technology outlook (revenue, millions of dollars, 2022-2030) based on water Gel polymer scaffold with micro-patterned surface micro-well plate nano-fiber-based scaffold hanging drop microwell plate scaffold 3D cell culture microfluidic ULAL coated spherical micro-plate 3D bioprinting and magnetic avoidance bioreactor application prospects (income, Millions of dollars, 2022-2030) Cancer engineering organization and immunohistochemistry drug development stem cell research and other end-use perspectives (revenue and 2.028 billion dollars) Industry biotechnology laboratories and research institutes hospitals and diagnostic centers others.


Geography Analysis:

The report further discusses the market opportunity, compound annual growth rate (CAGR) growth rate, competition, new technology innovations, market players analysis, government guidelines, export and import (EXIM) analysis, historical revenues, future forecasts etc. in the following regions and/or countries:

  • North America (U.S. & Canada) Market size, Y-O-Y growth, Market Players Analysis & Opportunity Outlook
  • Latin America (Brazil, Mexico, Argentina, Rest of Latin America) Market size, Y-O-Y growth & Market Players Analysis & Opportunity Outlook
  • Europe (U.K., Germany, France, Italy, Spain, Hungary, Belgium, Netherlands & Luxembourg, NORDIC(Finland, Sweden, Norway, Denmark), Ireland, Switzerland, Austria, Poland, Turkey, Russia, Rest of Europe), Poland, Turkey, Russia, Rest of Europe) Market size, Y-O-Y growth Market Players Analys  & Opportunity Outlook
  • Asia-Pacific (China, India, Japan, South Korea, Singapore, Indonesia, Malaysia, Australia, New Zealand, Rest of Asia-Pacific) Market size, Y-O-Y growth & Market Players Analysis & Opportunity Outlook
  • Middle East and Africa  (Israel, GCC (Saudi Arabia, UAE, Bahrain, Kuwait, Qatar, Oman), North Africa, South Africa, Rest of Middle East and Africa) Market size, Y-O-Y growth Market Players Analysis & Opportunity Outlook


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